MIT research is currently developing an advance space suit that uses exotic materials and mechanical counter-pressure to create a "second skin," in contrast to the bulky, inflated models currently used by astronauts.
MIT Researchers Take Space Suit to Next LevelThe skin-like layer would maintain pressure mechanically allowing you to create additional layers that can be donned more like clothing, quickly replaced or repaired. Tests have already shown that the mechanically applied pressure successfuly protects against exposure to vacuum, the problem would be to ensure such pressure can be maintained across the skin. Joints would be a problem. Work in "Shape Memory Polymers" and exploitation of so-called "lines of non-extension" on the human body would have to developed into the current design.
If successful, such suits could be in use for NASA lunar missions next decade and on a first mission to Mars.